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It is important to note that the increased impulsiveness reported in adolescent smokers might be a consequence, and not a predictor, of the addicted behavior. Converging studies using self-report questionnaire in teens demonstrated that impulsivity during adolescence was predictive of drug use and gambling Romer et al. Adolescents differ from adults in cocaine conditioned place preference and cocaine-induced dopamine in the nucleus accumbens septi. Science — Interestingly, the habituation of amygdala activity to these fearful faces was lower in subjects screened for high trait anxiety. Behavioral studies comparing juvenile and adult rodents revealed that mice displayed a greater preference for a novel environment Adriani et al. The juvenile period in rodents lasts from day 28 to day 42 after birth, but these limits, a bit restrictive, are usually extended to include a larger period from day 25 to day 55 Tirelli et al. Scopolamine and Pavlovian fear conditioning in rats:

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It is important to note that the increased impulsiveness reported in adolescent smokers might be a consequence, and not a predictor, of the addicted behavior. Converging studies using self-report questionnaire in teens demonstrated that impulsivity during adolescence was predictive of drug use and gambling Romer et al. Adolescents differ from adults in cocaine conditioned place preference and cocaine-induced dopamine in the nucleus accumbens septi. Science — Interestingly, the habituation of amygdala activity to these fearful faces was lower in subjects screened for high trait anxiety. Behavioral studies comparing juvenile and adult rodents revealed that mice displayed a greater preference for a novel environment Adriani et al. The juvenile period in rodents lasts from day 28 to day 42 after birth, but these limits, a bit restrictive, are usually extended to include a larger period from day 25 to day 55 Tirelli et al. Scopolamine and Pavlovian fear conditioning in rats:

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  1. Insights into the neurobiology of impulsive behavior from serotonin receptor knockout mice.

  2. This behavioral observation was correlated with an increased c-fos expression in the Nacc core and the dorsal striatum Friemel et al. Specifically, protracted development of prefrontal cortex PFC , in concert with an amplified motivational drive mediated by the striatum, is thought to be critical to increased novelty seeking and suboptimal decision making that leads to risky behavior and experimental drug use.

  3. However, no animal study has so far directly demonstrated an increased susceptibility to compulsive drug intake when first drug intoxication occurs during adolescence.

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